First, When we gain weight, inflammation in the body tissues increases. A key inflammatory marker in the blood known as C-reactive protein or (CRP) increases as weight increases. This inflammation is triggered by hormonal and metabolic changes and remains until excess weight is lost.
Second, inflammation in the body leads to insulin resistance. This is due to inflammatory compounds that impair the way insulin works. This causes higher glucose levels, kicking off a vicious cycle of weight gain causing more insulin resistance and insulin resistance leading to more weight gain.
Third, weight gain leads to leptin resistance. Leptin is a key hormone that tells the brain when to eat when to stop eating and when to speed up or slow down metabolism. Leptin function is negatively altered With weight gain and inflammation, so when leptin levels are low, appetite increases and metabolism slows.